In safavieh couture furniture an effort to discover new mouse models of cardiovascular disease using N-ethyl-N-nitrosourea (ENU) mutagenesis followed by high-throughput phenotyping, we have identified a new mouse mutation, C699Y, in the LDL receptor (Ldlr), named wicked high cholesterol (WHC).When WHC was compared with the widely used Ldlr knockout
It is well known that pH plays a pivotal role in the control of bone remodeling.However, no comprehensive gene expression data are available for the effects of alkaline pH on osteoblasts.We cultured differentiating MC3T3-E1 osteoblast-like cells at pH 7.4, 7.8, and 8.4 for 14 days.To identify easton speed comp -13 differential gene expression, micr
ObjectiveThe purpose of this study was to characterize similarities and differences in HPV vaccine misinformation narratives present in the comment sections of top-performing initial creator posts across three social media platforms.MethodsA qualitative multi-method design was used to analyze comments collected from social media posts.A sample of 2
Serine(S)/threonine(T)-glutamine(Q) cluster domains (SCDs), polyglutamine (polyQ) tracts and polyglutamine/asparagine (polyQ/N) tracts are Q-rich motifs found in many proteins.SCDs often are intrinsically disordered regions that mediate protein phosphorylation and protein-protein interactions.PolyQ and polyQ/N tracts are structurally flexible seque